Evaluation of the Safety, Immunogenicity, and Protective Efficacy of Whole Inactivated Simian Immunodeficiency Virus (SIV) Vaccines with Conformationally and Functionally Intact Envelope Glycoproteins

Abstract excerpt

A novel, general approach to chemical inactivation of retroviruses was used to produce inactivated simian immunodeficiency virus (SIV) particles with functional envelope glycoproteins. Inactivated virions of three different virus isolates (SIVmne E11S, SIVmac239, and SIVmac239 g4,5), prepared by treatment with 2,2'-dithiodipyridine (aldrithol-2, AT-2), were not detectably infectious, in vitro or in vivo....

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