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Article

BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks.

Blood - 1 Dec 2004

Nowicki Michal O, Falinski Rafal, Koptyra Mateusz, Slupianek Artur, Stoklosa Tomasz, Gloc Ewa, Nieborowska-Skorska Margaret, Blasiak Janusz, Skorski Tomasz

Abstract excerpt

The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chronic oxidative DNA damage resulting in double-strand breaks (DSBs) in S and G(2)/M cell cycle phases. These lesions are repaired by BCR/ABL-stimulated homologous recombination repair (HRR) and nonhomologous end-joining...

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Source

Identifiers

PMID: 15304390
DOI: 10.1182/blood-2004-05-1941

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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