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Article

Genomic instability: The cause and effect of BCR/ABL tyrosine kinase.

Current hematologic malignancy reports - 1 May 2007

Skorski Tomasz

Abstract excerpt

Genes encoding c-ABL kinase and BCR protein are targeted by yet-unknown mechanisms causing DNA double-strand breaks resulting in the generation of a chimeric gene encoding BCR/ABL fusion tyrosine kinase. BCR/ABL kinase displays transforming activity because of its constitutive kinase activity causing deregulated proliferation, apoptosis, differentiation, and adhesion. Moreover, BCR/ABL kinase is able to...

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Source

Identifiers

PMID: 20425353
DOI: 10.1007/s11899-007-0010-6

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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