Article
Identification of a pharmacogenetic effect by linkage disequilibrium mapping.
The pharmacogenomics journal - 1 Jan 2004
Xu C-F, Lewis K F, Yeo A J, McCarthy L C, Maguire M F, Anwar Z, Danoff T M, Roses A D, Purvis I J
Abstract excerpt
A practical limitation to the identification of genetic profiles predictive of drug-induced adverse events is the number of patients with the adverse event that can be tolerated before the drug is withdrawn. Whole genome screening for regions of linkage disequilibrium (LD) associated with a particular phenotype may provide the mechanism to rapidly discover specific and sensitive profiles. We have used data from a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.