Article
Death-associated protein 3 (Dap-3) is overexpressed in invasive glioblastoma cells in vivo and in glioma cell lines with induced motility phenotype in vitro.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2001
Mariani L, Beaudry C, McDonough W S, Hoelzinger D B, Kaczmarek E, Ponce F, Coons S W, Giese A, Seiler R W, Berens M E
Abstract excerpt
PURPOSE: To discover the genetic determinants of glioma invasion in vivo, we compared the mRNA expression profiles of glioblastoma cells residing at the tumor core versus those at the invasive rim of a human tumor resection. EXPERIMENTAL DESIGN: From a single glioblastoma specimen, 20,000 individual cells from each region (core and invasive rim) were collected by laser capture microdissection and analyzed by mRNA...
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