Article
Suppression of thymic lymphomas and increased nonthymic lymphomagenesis in Trp53-deficient mice lacking inducible nitric oxide synthase gene.
International journal of cancer - 10 Oct 2004
Tatemichi Masayuki, Tazawa Hiroshi, Masuda Mitsuharu, Saleem Mohammad, Wada Sayori, Donehower Lawrence A, Ohgaki Hiroko, Ohshima Hiroshi
Abstract excerpt
Trp53-deficient mice spontaneously develop lymphomas, mainly of thymic origin, although the molecular mechanism remains largely unknown. As several interaction effects between p53 and iNOS have been reported, we hypothesized that iNOS activity in the thymus is causally linked to lymphomagenesis in Trp53-deficient mice. We therefore created mouse strains with different combinations of the Trp53 and iNOS genes....
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