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Article

Caspase enzymology and activation mechanisms.

Methods in enzymology - 1 Jan 2014

Mace Peter D, Riedl Stefan J, Salvesen Guy S

Abstract excerpt

Apical caspases 8, 9, and 10 are only active as dimers. These dimers are unstable, and to characterize their activity they need to be maintained in vitro in a dimeric state. We provide updated methods for those looking to characterize various aspects of caspase function. We describe full methods for those looking to activate caspases in vitro using kosmotropic reagents, an essential step in characterizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24974290
DOI: 10.1016/B978-0-12-417158-9.00007-8

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