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Article

Association of human connexin40 gene polymorphisms with atrial vulnerability as a risk factor for idiopathic atrial fibrillation.

Circulation research - 20 Aug 2004

Firouzi Mehran, Ramanna Hemanth, Kok Bart, Jongsma Habo J, Koeleman Bobby P C, Doevendans Pieter A, Groenewegen W Antoinette, Hauer Richard N W

Abstract excerpt

Alterations in distribution, density, and properties of cardiac gap junctions, which mediate electrical coupling of cardiomyocytes, are considered potentially arrhythmogenic. We recently reported 2 linked polymorphisms within regulatory regions of the gene for the atrial gap junction protein connexin40 (Cx40) at nucleotides -44 (G-->A) and +71 (A-->G), which were associated with familial atrial standstill. The...

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Identifiers

PMID: 15297374
DOI: 10.1161/01.RES.0000141134.64811.0a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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