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Identification of a Conserved Region of<i>Plasmodium falciparum</i>MSP3 Targeted by Biologically Active Antibodies to Improve Vaccine Design

9 Aug 2004

Abstract excerpt

Merozoite surface protein 3 (MSP3) is a target of antibody-dependent cellular inhibition (ADCI), a protective mechanism against Plasmodium falciparum malaria. From the C-terminal half of the molecule, 6 overlapping peptides were chosen to characterize human immune responses. Each peptide defined at least 1 non-cross-reactive B cell epitope. Distinct patterns of antibody responses, by level and IgG subclass...

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PMID: 15295710
DOI: 10.1086/423208

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