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Article

Hsp105alpha suppresses Hsc70 chaperone activity by inhibiting Hsc70 ATPase activity.

The Journal of biological chemistry - 1 Oct 2004

Yamagishi Nobuyuki, Ishihara Keiichi, Hatayama Takumi

Abstract excerpt

Hsp105alpha is a mammalian member of the HSP105/110 family, a diverged subgroup of the HSP70 family. Hsp105alpha associates with Hsp70/Hsc70 as complexes in vivo and regulates the chaperone activity of Hsp70/Hsc70 negatively in vitro and in vivo. In this study, we examined the mechanisms by which Hsp105alpha regulates Hsc70 chaperone activity. Using a series of deletion mutants of Hsp105alpha and Hsc70, we found...

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Identifiers

PMID: 15292236
DOI: 10.1074/jbc.M407947200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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