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Article

Arginine 469 is a pivotal residue for the Hsc70-GlcNAc-binding property.

Biochemical and biophysical research communications - 1 Oct 2010

Guinez Céline, Mir Anne-Marie, Martin Nathalie, Leprince Dominique, Michalski Jean-Claude, Vergoten Gérard, Lefebvre Tony

Abstract excerpt

The members of the 70kDa-heat shock proteins (HSP70) family play numerous fundamental functions in the cell such as promoting the assembly of multimeric complexes or helping the correct folding of nascent proteins to take place. In numerous previous studies we demonstrated that Hsp70 and its constitutive isoform Hsc70 are endowed of a GlcNAc-binding activity. The molecular modeling of the substrate binding domain...

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Identifiers

PMID: 20804732
DOI: 10.1016/j.bbrc.2010.08.089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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