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Article

Mammalian Hsp70 and Hsp110 proteins bind to RNA motifs involved in mRNA stability.

The Journal of biological chemistry - 11 Jun 1999

Henics T, Nagy E, Oh H J, Csermely P, von Gabain A, Subjeck J R

Abstract excerpt

In this study, in vitro RNA binding by members of the mammalian 70-kDa heat shock protein (Hsp) family was examined. We show that Hsp/Hsc70 and Hsp110 proteins preferentially bound AU-rich RNA in vitro. Inhibition of RNA binding by ATP suggested the involvement of the N-terminal ATP-binding domain. By using deletion mutants of Hsp110 protein, a diverged Hsp70 family member, RNA binding was localized to the...

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Identifiers

PMID: 10358092
DOI: 10.1074/jbc.274.24.17318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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