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Article

Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.

Journal of bacteriology - 1 Aug 2004

Xu Hai, Zhang Yuzhen, Guo Xiaokui, Ren Shuangxi, Staempfli Andreas A, Chiao Juishen, Jiang Weihong, Zhao Guoping

Abstract excerpt

Three leuA-like protein-coding sequences were identified in Leptospira interrogans. One of these, the cimA gene, was shown to encode citramalate synthase (EC 4.1.3.-). The other two encoded alpha-isopropylmalate synthase (EC 4.1.3.12). Expressed in Escherichia coli, the citramalate synthase was purified and characterized. Although its activity was relatively low, it was strictly specific for pyruvate as the keto...

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Identifiers

PMID: 15292141
DOI: 10.1128/JB.186.16.5400-5409.2004
PMCID: PMC490871

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Source receipt: pubmed, retrieved 7 Sept 2026.

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