Escherichia coli D-malate dehydrogenase, a generalist enzyme active in the leucine biosynthesis pathway.

doi:10.1074/jbc.M114.595363

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Article

Escherichia coli D-malate dehydrogenase, a generalist enzyme active in the leucine biosynthesis pathway.

The Journal of biological chemistry - 17 Oct 2014

Vorobieva Anastassia A, Khan Mohammad Shahneawz, Soumillion Patrice

Abstract excerpt

The enzymes of the β-decarboxylating dehydrogenase superfamily catalyze the oxidative decarboxylation of D-malate-based substrates with various specificities. Here, we show that, in addition to its natural function affording bacterial growth on D-malate as a carbon source, the D-malate dehydrogenase of Escherichia coli (EcDmlA) naturally expressed from its chromosomal gene is capable of complementing leucine...

Topics

Catalysis
Chromosomes, Bacterial
Cloning, Molecular
Escherichia coli
Escherichia coli Proteins
Fluorometry
Leucine
Malate Dehydrogenase
Phenotype
Phylogeny
Promoter Regions, Genetic

Source

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Identifiers

PMID: 25160617
DOI: 10.1074/jbc.M114.595363
PMCID: PMC4200263

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