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Article

Akt-dependent phosphorylation negatively regulates the transcriptional activity of dHAND by inhibiting the DNA binding activity.

European journal of biochemistry - 1 Aug 2004

Murakami Masao, Kataoka Keiichiro, Fukuhara Shigetomo, Nakagawa Osamu, Kurihara Hiroki

Abstract excerpt

HAND2/dHAND is a basic helix-loop-helix transcription factor expressed in the heart and neural crest derivatives during embryogenesis. Although dHAND is essential for branchial arch, cardiovascular and limb development, its target genes have not been identified. The regulatory mechanisms of dHAND function also remain relatively unknown. Here we report that Akt/PKB, a serine/threonine protein kinase involved in...

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Source

Identifiers

PMID: 15291810
DOI: 10.1111/j.1432-1033.2004.04267.x

Genes

HAND2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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