Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progression of pregnancy-dependent mouse mammary tumors after long dormancy periods. Involvement of Wnt pathway activation.

Cancer research - 1 Aug 2004

Gattelli Albana, Cirio María Cecilia, Quaglino Ana, Schere-Levy Carolina, Martinez Natalia, Binaghi María, Meiss Roberto P, Castilla Lucio H, Kordon Edith C

Abstract excerpt

Mouse mammary tumor virus (LA) induces pregnancy-dependent mammary tumors that progress toward autonomy. Here we show that in virgin females, pregnancy-dependent tumor transplants are able to remain dormant for up to 300 days. During that period, these tumors synthesize DNA, express high levels of estrogen and progesterone receptors (ER+PR+) and are able to resume growth after hormone stimulation. Surprisingly,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibroblast Growth Factor 3
Share to Fibroblast Growth Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Experimental

Share to Mammary Tumor Virus, Mouse

Share to Neoplasm Transplantation

Share to Neoplasms, Hormone-Dependent

Share to Pregnancy Complications, Neoplastic

Share to Receptors, Progesterone

Source

Identifiers

PMID: 15289324
DOI: 10.1158/0008-5472.CAN-03-3992

Genes

GEM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progression of pregnancy-dependent mouse mammary tumors after long dormancy periods. Involvement of Wnt pathway activation.PMID 15289324Read ↗

Cellular dormancy in minimal residual disease following targeted therapySemantic proximity Read ↗

Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines.Semantic proximity Read ↗

Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis.Semantic proximity Read ↗

Breast cancer dormancy is associated with a 4NG1 state and not senescenceSemantic proximity Read ↗

Live Cell Lineage Tracing of Dormant Cancer CellsSemantic proximity Read ↗

Contribution of an alveolar cell of origin to the high-grade malignant phenotype of pregnancy-associated breast cancer.Semantic proximity Read ↗

Clinical Tumor Dormancy.Semantic proximity Read ↗

Expression of Brca1 and splice variant Brca1delta11 RNA levels in mouse mammary gland during normal development and tumorigenesis.Semantic proximity Read ↗

Tumor cell-organized fibronectin is required to maintain a dormant breast cancer populationSemantic proximity Read ↗

Adult mouse myometrial label-retaining cells divide in response to gonadotropin stimulation.Semantic proximity Read ↗

Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss.Semantic proximity Read ↗

Persistent Parity-Induced Changes in Growth Factors, TGF-β3, and Differentiation in the Rodent Mammary GlandSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.