Article
Tumor cell-organized fibronectin is required to maintain a dormant breast cancer population
2019-07-01
Abstract excerpt
Tumors can undergo long periods of dormancy, with cancer cells entering a largely quiescent, non-proliferative state before reactivation and outgrowth. For a patient, these post-remission tumors are often drug resistant and highly aggressive, resulting in poor prognosis. To understand the role of the extracellular matrix (ECM) in regulating tumor dormancy, we created an in vitro cell culture system that combines...
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Identifiers and source
- Literature Corpus work
- 75ecfd32-a661-5cc7-b2ba-62ced1d1f26d
- DOI
- 10.1101/686527