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Article

Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines.

Journal of virology - 1 Nov 2006

Gattelli Albana, Zimberlin María N, Meiss Roberto P, Castilla Lucio H, Kordon Edith C

Abstract excerpt

Mice harboring three mouse mammary tumor virus (MMTV) variants develop pregnancy-dependent (PD) tumors that progress to pregnancy-independent (PI) behavior through successive passages. Herein, we identified 10 predominant insertions in PI transplants from 8 independent tumor lines. These mutations were also detected in small cell populations in the early PD passages. In addition, we identified a new viral...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16971449
DOI: 10.1128/JVI.00234-06
PMCID: PMC1642155

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Source receipt: pubmed, retrieved 7 Sept 2026.

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