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Article

Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss.

The Journal of clinical investigation - 1 Jan 2008

Debies Michael T, Gestl Shelley A, Mathers Jessica L, Mikse Oliver R, Leonard Travis L, Moody Susan E, Chodosh Lewis A, Cardiff Robert D, Gunther Edward J

Abstract excerpt

Breast cancers frequently progress or relapse during targeted therapy, but the molecular mechanisms that enable escape remain poorly understood. We elucidated genetic determinants underlying tumor escape in a transgenic mouse model of Wnt pathway-driven breast cancer, wherein targeted therapy is simulated by abrogating doxycycline-dependent Wnt1 transgene expression within established tumors. In mice with intact...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18060046
DOI: 10.1172/JCI33320
PMCID: PMC2104482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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