Article
Haplotype reconstruction from SNP alignment.
Journal of computational biology : a journal of computational molecular cell biology - 1 Jan 2004
Li Lei M, Kim Jong Hyun, Waterman Michael S
Abstract excerpt
In this paper, we describe a method for statistical reconstruction of haplotypes from a set of aligned SNP fragments. We consider the case of a pair of homologous human chromosomes, one from the mother and the other from the father. After fragment assembly, we wish to reconstruct the two haplotypes of the parents. Given a set of potential SNP sites inferred from the assembly alignment, we wish to divide the...
Topics
- Base Sequence
- Computational Biology
- Computer Simulation
- Genotype
- Haplotypes
- Models, Genetic
- Polymorphism, Single Nucleotide
- Sequence Alignment