Article
Haplotype reconstruction using perfect phylogeny and sequence data.
BMC bioinformatics - 19 Apr 2012
Efros Anatoly, Halperin Eran
Abstract excerpt
Haplotype phasing is a well studied problem in the context of genotype data. With the recent developments in high-throughput sequencing, new algorithms are needed for haplotype phasing, when the number of samples sequenced is low and when the sequencing coverage is blow. High-throughput sequencing technologies enables new possibilities for the inference of haplotypes. Since each read is originated from a single...
Topics
- Algorithms
- Disease
- Genetic Association Studies
- Genotype
- Haplotypes
- High-Throughput Nucleotide Sequencing
- Humans
- Models, Statistical
- Phylogeny
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA