Article
Relative impact of covariates in prescribing warfarin according to CYP2C9 genotype.
Pharmacogenetics - 1 Aug 2004
Hillman Michael A, Wilke Russell A, Caldwell Michael D, Berg Richard L, Glurich Ingrid, Burmester James K
Abstract excerpt
Patients on warfarin anticoagulant therapy demonstrate wide variation in maintenance dose. Patients possessing variants (*2 and *3) of the cytochrome P450 2C9 gene require reduced maintenance doses compared to those having wild-type alleles (*1). Many other clinical factors have been shown to affect warfarin dose as well. To determine the relative impact of CYP2C9 genotype, age, gender, body surface area,...
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