Article
The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin.
Journal of the American College of Surgeons - 1 Mar 2002
Tabrizi Arash Rafii, Zehnbauer Barbara A, Borecki Ingrid B, McGrath Sean D, Buchman Timothy G, Freeman Bradley D
Abstract excerpt
BACKGROUND: Warfarin sodium (warfarin) is commonly prescribed in surgical practice. Warfarin use is complicated by an unpredictable dose response that may be due in part to genetically determined differences in metabolic capacity. To better understand the interaction between genotype and response to warfarin therapy, we determined the frequency and functional effects of polymorphisms of the predominant cytochrome...
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