Article
An adult osteopetrosis model in medaka reveals the importance of osteoclast function for bone remodeling in teleost fish.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP - 1 Dec 2015
To Thuy Thanh, Witten Paul Eckhard, Huysseune Ann, Winkler Christoph
Abstract excerpt
Osteoclasts play important roles during bone growth and in maintaining bone health and bone homeostasis. Dysfunction or lack of osteoclasts leads to increased bone mass and osteopetrosis phenotypes in mouse and human. Here we report a severe osteopetrosis-like phenotype in transgenic medaka fish, in which membrane bound EGFP (mEGFP) was expressed in osteoclasts under control of the cathepsin K promoter...
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