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Article

Fast and accurate predictions of protein stability changes upon mutations using statistical potentials and neural networks: PoPMuSiC-2.0.

Bioinformatics (Oxford, England) - 1 Oct 2009

Dehouck Yves, Grosfils Aline, Folch Benjamin, Gilis Dimitri, Bogaerts Philippe, Rooman Marianne

Abstract excerpt

MOTIVATION: The rational design of proteins with modified properties, through amino acid substitutions, is of crucial importance in a large variety of applications. Given the huge number of possible substitutions, every protein engineering project would benefit strongly from the guidance of in silico methods able to predict rapidly, and with reasonable accuracy, the stability changes resulting from all possible...

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Identifiers

PMID: 19654118
DOI: 10.1093/bioinformatics/btp445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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