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Article

Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2004

Yu Xiaojun, Botchwey Edward A, Levine Elliot M, Pollack Solomon R, Laurencin Cato T

Abstract excerpt

An important issue in tissue engineering concerns the possibility of limited tissue ingrowth in tissue-engineered constructs because of insufficient nutrient transport. We report a dynamic flow culture system using high-aspect-ratio vessel rotating bioreactors and 3D scaffolds for culturing rat calvarial osteoblast cells. 3D scaffolds were designed by mixing lighter-than-water (density, <1g/ml) and...

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Identifiers

PMID: 15277663
DOI: 10.1073/pnas.0402532101
PMCID: PMC509184

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Source receipt: pubmed, retrieved 7 Sept 2026.

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