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Ex vivo 3D osteocyte network construction with primary murine bone cells

14 Sept 2015

Abstract excerpt

Osteocytes reside as three-dimensionally (3D) networked cells in the lacunocanalicular structure of bones and regulate bone and mineral homeostasis. Despite of their important regulatory roles, in vitro studies of osteocytes have been challenging because: (1) current cell lines do not sufficiently represent the phenotypic features of mature osteocytes and (2) primary cells rapidly differentiate to osteoblasts...

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PMID: 26421212
DOI: 10.1038/boneres.2015.26

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