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Article

A novel bidirectional continuous perfusion bioreactor for the culture of large-sized bone tissue-engineered constructs.

Journal of biomedical materials research. Part B, Applied biomaterials - 1 Nov 2013

Gardel Leandro S, Correia-Gomes Carla, Serra Luís A, Gomes Manuela E, Reis Rui L

Abstract excerpt

This works reports the development and preliminary assessment of a new bioreactor for culturing large-sized three-dimensional constructs in bone tissue engineering. The bidirectional continuous perfusion bioreactor (BCPB) promotes mechanical stimulation of cells through the creation of shear forces induced by flow perfusion. The main innovation consists in the possibility of culturing scaffolds of large...

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PMID: 23681695
DOI: 10.1002/jbm.b.32955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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