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Article

Can Shaker potassium channels be locked in the deactivated state?

The Journal of general physiology - 1 Aug 2004

Yang Youshan, Yan Yangyang, Sigworth Fred J

Abstract excerpt

For structural studies it would be useful to constrain the voltage sensor of a voltage-gated channel in its deactivated state. Here we consider one Shaker potassium channel mutant and speculate about others that might allow the channel to remain deactivated at zero membrane potential. Ionic and gating currents of F370C Shaker, expressed in Xenopus oocytes, were recorded in patches with internal application of the...

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Identifiers

PMID: 15277577
DOI: 10.1085/jgp.200409057
PMCID: PMC2229620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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