Article
Insulin and TNFα Induce Expression of the Forkhead Transcription Factor Gene<i>Foxc2</i>in 3T3-L1 Adipocytes via PI3K and ERK 1/2-Dependent Pathways
1 Apr 2002
Abstract excerpt
We have recently identified the winged helix/forkhead gene Foxc2 as a key regulator of adipocyte metabolism that counteracts obesity and diet-induced insulin resistance. This study was performed to elucidate the hormonal regulation of Foxc2 in adipocytes. We find that TNF alpha and insulin induce Foxc2 mRNA in differentiated 3T3-L1 cells with the kinetics of an immediate early response (1-2 h with 100 ng/ml...
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