Article
Function of GATA transcription factors in preadipocyte-adipocyte transition.
Science (New York, N.Y.) - 6 Oct 2000
Tong Q, Dalgin G, Xu H, Ting C N, Leiden J M, Hotamisligil G S
Abstract excerpt
Genes that control the early stages of adipogenesis remain largely unknown. Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. Constitutive GATA-2 and GATA-3 expression suppressed adipocyte differentiation and trapped cells at the preadipocyte stage. This effect is mediated, at least in...
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