Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity.

doi:10.1002/ajmg.b.30047

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Aug 2004

Thompson Miles D, Comings David E, Abu-Ghazalah Rashid, Jereseh Yousef, Lin Leo, Wade Judy, Sakurai Takeshi, Tokita Shigeru, Yoshida Tetsuo, Tanaka Hirokazu, Yanagisawa Masashi, Burnham W McIntyre, Moldofsky Harvey

Abstract excerpt

The orexin-2/hypocretin-2 (OX2R) receptor gene is mutated in canine narcolepsy and disruption of the prepro-orexin/hypocretin ligand gene results in both an animal model of narcolepsy and sporadic cases of the human disease. This evidence suggests that the structure of the OX2R gene, and its homologue, the OX1R gene, both members of the G protein-coupled receptor (GPCR) family, and the gene encoding the peptide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Comorbidity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Space

Share to Neuropeptides

Share to Orexin Receptors

Share to Orexins

Share to Receptors, G-Protein-Coupled

Share to Receptors, Neuropeptide

Share to Tourette Syndrome

Source

Open in PubMed

Identifiers

PMID: 15274044
DOI: 10.1002/ajmg.b.30047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity.PMID 15274044Read ↗

Sleep, sleep disorders and hypocretin (orexin).Semantic proximity Read ↗

Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines.Semantic proximity Read ↗

Hypocretin (orexin) neuropeptide precursor gene, HCRT, polymorphisms in early-onset narcolepsy with cataplexy.Semantic proximity Read ↗

Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.Semantic proximity Read ↗

Hypocretins/orexins as integrators of physiological information: lessons from mutant animals.Semantic proximity Read ↗

A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache.Semantic proximity Read ↗

Haplotype analysis confirms the association between the HCRTR2 gene and cluster headache.Semantic proximity Read ↗

The hypocretin/orexin system in health and disease.Semantic proximity Read ↗

Narcolepsy and familial advanced sleep-phase syndrome: molecular genetics of sleep disorders.Semantic proximity Read ↗

Narcolepsy and the hypocretin receptor 2 gene.Semantic proximity Read ↗

Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.Semantic proximity Read ↗

Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.