Article
Hypocretin (orexin) neuropeptide precursor gene, HCRT, polymorphisms in early-onset narcolepsy with cataplexy.
Sleep medicine - 1 Jun 2013
Dong Xiao Song, Ma Su Fang, Cao Chun Wei, Li Jing, An Pei, Zhao Long, Liu Nan Y, Yan Han, Hu Qing Tao, Mignot Emmanuel, Strohl Kingman P, Gao Zhan C, Zeng Changqing, Han Fang
Abstract excerpt
BACKGROUND: To test if the hypocretin (orexin) neuropeptide precursor (HCRT) gene, HCRT, mutations are implicated in the development of narcolepsy with cataplexy deficiency in young children. METHODS: The entire HCRT gene and ~2000 bp promoter region was first sequenced in 181 patients and 153 controls, and rare polymorphisms including three nonsynonymous amino acid changes were identified. Next the 557 bp region...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.