Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.

doi:10.1126/science.1098801

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Article

Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.

Science (New York, N.Y.) - 23 Jul 2004

Aspholm-Hurtig Marina, Dailide Giedrius, Lahmann Martina, Kalia Awdhesh, Ilver Dag, Roche Niamh, Vikström Susanne, Sjöström Rolf, Lindén Sara, Bäckström Anna, Lundberg Carina, Arnqvist Anna, Mahdavi Jafar, Nilsson Ulf J, Velapatiño Billie, Gilman Robert H, Gerhard Markus, Alarcon Teresa, López-Brea Manuel, Nakazawa Teruko, Fox James G, Correa Pelayo, Dominguez-Bello Maria Gloria, Perez-Perez Guillermo I, Blaser Martin J, Normark Staffan, Carlstedt Ingemar, Oscarson Stefan, Teneberg Susann, Berg Douglas E, Borén Thomas

Abstract excerpt

Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains...

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PMID: 15273394
DOI: 10.1126/science.1098801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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