Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Construction and Characterization of Hexon-Chimeric Adenoviruses: Specification of Adenovirus Serotype

1 Dec 1998

Abstract excerpt

This study has used the strategy of gene replacement to characterize the contribution of the adenovirus (Ad) capsid protein hexon to serotype definition. By replacing the Ad type 5 (Ad5) hexon gene with sequences from Ad2, we have changed the type specificity of the chimeric virus. The type-determining epitopes are primarily associated with loop 1 of hexon and, to a much lesser degree, with loop 2. In spite of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Viral gastroenteritis research and epidemiology
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9811772
DOI: 10.1128/jvi.72.12.10260-10264.1998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Construction and Characterization of Hexon-Chimeric Adenoviruses: Specification of Adenovirus SerotypePMID 9811772Read ↗

Type-Specific Epitope Locations Revealed by X-Ray Crystallographic Study of Adenovirus Type 5 HexonSemantic proximity Read ↗

Construction and Characterization of Adenovirus Serotype 5 Packaged by Serotype 3 HexonSemantic proximity Read ↗

Identification of Hexon-Specific CD4 and CD8 T-Cell Epitopes for Vaccine and ImmunotherapySemantic proximity Read ↗

The CD4+ T-cell response to adenovirus is focused against conserved residues within the hexon proteinSemantic proximity Read ↗

Comparative sequence analysis of the hexon gene in the entire spectrum of human adenovirus serotypes: phylogenetic, taxonomic, and clinical implications.Semantic proximity Read ↗

Expression of a foreign epitope on the surface of the adenovirus hexonSemantic proximity Read ↗

Overcoming pre-existing adenovirus immunity by genetic engineering of adenovirus-based vectorsSemantic proximity Read ↗

Analysis of 15 adenovirus hexon proteins reveals the location and structure of seven hypervariable regions containing serotype-specific residuesSemantic proximity Read ↗

Identification of Sites in Adenovirus Hexon for Foreign Peptide IncorporationSemantic proximity Read ↗

Adenovirus Type 6: Subtle Structural Distinctions from Adenovirus Type 5 Result in Essential Differences in Properties and Perspectives for Gene TherapySemantic proximity Read ↗

Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells.Semantic proximity Read ↗

Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.