Article
Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis.
Molecular cell - 1 Dec 2001
Irminger-Finger I, Leung W C, Li J, Dubois-Dauphin M, Harb J, Feki A, Jefford C E, Soriano J V, Jaconi M, Montesano R, Krause K H
Abstract excerpt
The BRCA1-associated protein BARD1 is a putative tumor suppressor. We suggest that BARD1 is a mediator of apoptosis since (1) cell death in vivo (ischemic stroke) and in vitro is accompanied by increased levels of BARD1 protein and mRNA; (2) overexpression of BARD1 induces cell death with all features of apoptosis; and (3) BARD1-repressed cells are defective for the apoptotic response to genotoxic stress. The...
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