Is there more to BARD1 than BRCA1?

Abstract excerpt

It has been over a decade since mutations in BRCA1 and BRCA2 were found to be associated with a small number of familial breast cancer cases. BRCA1 is a large protein that interacts with many other proteins that have diverse functions, so it has been a challenge to determine how defects in its function could lead to cancer. One particular protein, BARD1, seems to be an important regulator of the tumour-suppressor...

Topics

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• BRCA1 Protein
• Breast Neoplasms
• Forecasting
• BARD1 gene
• Genetic Predisposition to Disease
• Germ-Line Mutation