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Article

Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis.

International journal of cancer - 1 Mar 2006

Wu Jian-Yu, Vlastos Anne-Therese, Pelte Marie-Françoise, Caligo Maria-Adelaide, Bianco Andrea, Krause Karl-Heinz, Laurent Geoffrey J, Irminger-Finger Irmgard

Abstract excerpt

Mutations in tumor-suppressor gene BARD1 have been found in inherited and spontaneous breast, ovarian and uterine cancers. BARD1 plays a critical role in DNA repair and ubiquitination as binding partner of BRCA1, with which it colocalizes to nuclear dots. Independently of BRCA1, BARD1 can induce p53-dependent apoptosis in response to genotoxic stress. Therefore, BARD1 or p53 might be defective in cancer cells...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Gene Expression Regulation, Neoplastic

Share to Ovarian Neoplasms

Share to Tumor Suppressor Protein p53

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Source

Identifiers

PMID: 16152612
DOI: 10.1002/ijc.21428

Genes

BARD1
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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