Article
Multilineage progression of genetically unstable tumor subclones in cutaneous T-cell lymphoma.
Experimental dermatology - 1 Aug 2004
Rübben Albert, Kempf Werner, Kadin Marshall E, Zimmermann Dieter R, Burg Günter
Abstract excerpt
Molecular analysis of solid malignant tumors has suggested multilineage progression of genetically unstable subclones during early stages of tumorigenesis as a common mechanism of tumor cell evolution. We have investigated whether multilineage progression is a feature of cutaneous T-cell lymphoma (CTCL). To identify individual tumor cell subclones, we determined the pattern of mutations within microsatellite DNA...
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