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Article

Molecular Genetic Demonstration of the Evolution of Transformed Mycosis Fungoides: A Clinicopathological and Molecular Case Study.

Journal of cutaneous pathology - 1 Jul 2026

Cheng Melissa, Crisan Liliana, Zain Jasmine, Afkhami Michelle, Querfeld Christiane

Abstract excerpt

Large cell transformation (LCT) in mycosis fungoides (MF) is thought to represent the clonal evolution of a single clone and is associated with aggressive clinical behavior and poor outcome not overcome by aggressive treatment regimens. The tumor dynamics leading to LCT-MF are poorly understood and previously determined genetic alterations in MF do not explain nor can predict disease progression and/or...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41873173
DOI: 10.1111/cup.70095

Genes

LCT
ATM
CARD11
CDK6
CDKN2A
CDKN2B
EIF4E
IKZF1
NRAS
PLCG1
TET2
TP53
U2AF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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