Article

Independent evolution of cutaneous lymphoma subclones in different microenvironments of the skin

2019-11-04

Abstract excerpt

Mycosis fungoides (MF) is the most common, yet incurable, cutaneous T-cell lymphoma. We have recently shown that the disease is initiated by hematogenous seeding the skin with clonotypically diverse neoplastic T-cells which proliferate accumulating numerous mutations and produce lesions of high intratumoral heterogeneity (ITH). A characteristic but a poorly studied feature of MF is epidermotropism, the tendency to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 576faff1-b37c-5fa8-a7b4-f2dbfe18a59d
DOI: 10.1101/829671

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Independent evolution of cutaneous lymphoma subclones in different microenvironments of the skinDOI 10.1101/829671Read

Independent evolution of cutaneous lymphoma subclones in different microenvironments of the skin.Semantic proximity Read

Branched evolution and genomic intratumor heterogeneity in the pathogenesis of cutaneous T-cell lymphomaSemantic proximity Read

Branched evolution and genomic intratumor heterogeneity in the pathogenesis of cutaneous T-cell lymphomaSemantic proximity Read

Mycosis Fungoides Is a Proliferation of Multiple Mutational Subclones.Semantic proximity Read

Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphomaSemantic proximity Read

Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphomaSemantic proximity Read

Clonotypic Diversity of the T-cell Receptor Corroborates the Immature Precursor Origin of Cutaneous T-cell LymphomaSemantic proximity Read

Cutaneous T cell lymphoma atlas reveals malignant Th2 cells supported by a B cell-rich microenvironmentSemantic proximity Read

The mycosis fungoides cutaneous microenvironment shapes dysfunctional cell trafficking, antitumor immunity, matrix interactions, and angiogenesisSemantic proximity Read

Clonotypic Heterogeneity In Cutaneous T-Cell Lymphoma Revealed By Comprehensive Whole Exome/Transcriptome SequencingSemantic proximity Read

Clonotypic heterogeneity in cutaneous T-cell lymphoma (mycosis fungoides) revealed by comprehensive whole-exome sequencingSemantic proximity Read

Single-cell RNA sequencing identifies subtypes of cancer-associated fibroblasts in early and late stages of mycosis fungoidesSemantic proximity Read