Article
p53 gene codon 72 polymorphism but not tumor necrosis factor-alpha gene is associated with prostate cancer.
Urologia internationalis - 1 Jan 2004
Wu Hsi-Chin, Chang Chao-Hsiang, Chen Huey-Yi, Tsai Fuu-Jen, Tsai Jeffery J P, Chen Wen-Chi
Abstract excerpt
OBJECTIVE: A polymorphism of gene p53 codon 72 is associated with various cancer formations. Tumor necrosis factor-alpha (TNF-alpha) one of the cytokines secreted by macrophages in response to inflammation and is also related to cancer formation. We aimed to evaluate the association between prostate cancer and the polymorphisms of the TNF-alpha gene promoter -308 and p53 gene codon 72. PATIENTS AND METHODS: In...
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