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Article

Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion.

Diabetologia - 1 Aug 2004

Johansen A, Nielsen E-M D, Andersen G, Hamid Y H, Jensen D P, Glümer C, Drivsholm T, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O

Abstract excerpt

AIMS/HYPOTHESIS: Polymorphisms of the butyrylcholinesterase gene (BCHE) are reported to associate with Alzheimer's disease and a recent study found a significant association of the BCHE K variant (G1615A/Ala539Thr) with Type 2 diabetes. The objectives of our study were to examine whether the BCHE K variant is associated with Type 2 diabetes or estimates of pancreatic beta cell function in large-scale populations...

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Source

Identifiers

PMID: 15258737
DOI: 10.1007/s00125-004-1459-7

Genes

BCHE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion.PMID 15258737Read ↗

Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects.Semantic proximity Read ↗

The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease.Semantic proximity Read ↗

Butyrylcholinesterase K variant and Alzheimer's disease risk: a meta-analysis.Semantic proximity Read ↗

Variant K of butyrylcholinesterase and types 1 and 2 of diabetes mellitus.Semantic proximity Read ↗

No association between butyrylcholinesterase K-variant and Alzheimer disease in Chinese.Semantic proximity Read ↗

No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer's disease.Semantic proximity Read ↗

Association of Butyrylcholinesterase-K Allele and Apolipoprotein E ɛ4 Allele with Cognitive Decline in Dementia with Lewy Bodies and Alzheimer's Disease.Semantic proximity Read ↗

Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans.Semantic proximity Read ↗

Homozygosity for the K variant of BCHE gene increases the risk for development of neurofibrillary pathology but not amyloid deposits at young ages.Semantic proximity Read ↗

Frequency and enzyme activity of the butyrylcholinesterase K-variant in a Turkish population.Semantic proximity Read ↗

No association between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease.Semantic proximity Read ↗

Butyrylcholinesterase K variant and cerebral amyloid angiopathy.Semantic proximity Read ↗

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