Article

Sirtuin activators as an anti-aging intervention for longevity

2025-01-12

Abstract excerpt

Sirtuins are a family of NAD+-dependent class III histone deacetylases that regulate histones and other proteins. The mammalian sirtuins comprise seven members that have a role in energy metabolism, DNA repair, inflammation, cell survival, apoptosis, cellular senescence, oxidative stress, and mitochondrial production. Sirtuin modulation may have beneficial effects on aging and age-related diseases; thus, attractin...

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Literature Corpus work: 1269bd97-1f8d-5912-969f-606d3aab7dc8
DOI: 10.37349/eds.2025.100881

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