Article
A conserved element in the yeast RNase MRP RNA subunit can participate in a long-range base-pairing interaction.
Journal of molecular biology - 6 Aug 2004
Walker Scott C, Avis Johanna M
Abstract excerpt
RNase MRP is a ribonucleoprotein endoribonuclease involved in eukaryotic pre-rRNA processing. The enzyme possesses a putatively catalytic RNA subunit, structurally related to that of RNase P. A thorough structure analysis of Saccharomyces cerevisiae MRP RNA, entailing enzymatic and chemical probing, mutagenesis and thermal melting, identifies a previously unrecognised stem that occupies a position equivalent to...
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