Article
Captured retroviral envelope syncytin gene associated with the unique placental structure of higher ruminants.
Proceedings of the National Academy of Sciences of the United States of America - 26 Feb 2013
Cornelis Guillaume, Heidmann Odile, Degrelle Séverine A, Vernochet Cécile, Lavialle Christian, Letzelter Claire, Bernard-Stoecklin Sibylle, Hassanin Alexandre, Mulot Baptiste, Guillomot Michel, Hue Isabelle, Heidmann Thierry, Dupressoir Anne
Abstract excerpt
Syncytins are envelope genes of retroviral origin that have been co-opted for a role in placentation and likely contribute to the remarkable diversity of placental structures. Independent capture events have been identified in primates, rodents, lagomorphs, and carnivores, where they are involved in the formation of a syncytium layer at the fetomaternal interface via trophoblast cell-cell fusion. We searched for...
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