Article
An infectious clone of enterovirus 71(EV71) that is capable of infecting neonatal immune competent mice without adaptive mutations.
Emerging microbes & infections - 1 Jan 2020
Zhang Huiying, Song Zhigang, Zou Jingyi, Feng Yanling, Zhang Jing, Ren Lehao, Zhang Xiaonan, Hu Yunwen, Yuan Zhenghong, Yi Zhigang
Abstract excerpt
Enterovirus 71 (EV71) is a major pathogen that causes hand, foot and mouth disease (HFMD), which is a life threatening disease in certain children. The pathogenesis of EV71-caused HFMD is poorly defined due to the lack of simple and robust animal models with severe phenotypes that recapitulate symptoms observed in humans. Here, we generated the infectious clone of a clinical isolate from a severe HFMD patient....
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