Article
Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene.
Human molecular genetics - 15 Sept 2004
Hertzano Ronna, Montcouquiol Mireille, Rashi-Elkeles Sharon, Elkon Rani, Yücel Raif, Frankel Wayne N, Rechavi Gideon, Möröy Tarik, Friedman Thomas B, Kelley Matthew W, Avraham Karen B
Abstract excerpt
Pou4f3 (Brn3.1, Brn3c) is a class IV POU domain transcription factor that has a central function in the development of all hair cells in the human and mouse inner ear sensory epithelia. A mutation of POU4F3 underlies human autosomal dominant non-syndromic progressive hearing loss DFNA15. Through a comparison of inner ear gene expression profiles of E16.5 wild-type and Pou4f3 mutant deaf mice using a high density...
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