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Article

Inhibition of Myo6 gene expression by co‑expression of a mutant of transcription factor POU4F3 (BRN‑3C) in hair cells.

Molecular medicine reports - 1 Apr 2014

Ma Deng-Bin, Chen Jie, Xia Yang, Zhu Guang-Jie, Ma Xiao-Feng, Zhou Han, Gu Ya-Jun, Yu Chen-Jie, Zhu Min-Sheng, Qian Xiao-Yun, Gao Xia

Abstract excerpt

An eight‑base pair (bp) deletion in the Pou4f3 gene in hair cells is associated with DFNA15, a hereditary form of hearing loss. To explore the pathological mechanisms underlying the development of DFNA15, the effect of the mutation in Pou4f3 on the activity of the myosin VI (Myo6) promoter, was investigated. The upstream regulatory sequence of Myo6 (2625 bp), consisting of an 1899 bp upstream sequence and a 727...

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PMID: 24535414
DOI: 10.3892/mmr.2014.1953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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