Article
Testicular phenotype in luteinizing hormone receptor knockout animals and the effect of testosterone replacement therapy.
Biology of reproduction - 1 Nov 2004
Lei Z M, Mishra S, Ponnuru P, Li X, Yang Z W, Rao Ch V
Abstract excerpt
The LH receptor knockout model, developed in our laboratory, was used in determining what FSH alone can do in the absence of LH signaling and whether any of the testicular LH actions are not mediated by androgens. The results revealed that null animals contained smaller seminiferous tubules, which contained the same number of Sertoli cells, spermatogonia, and early spermatocytes as wild-type siblings. The number...
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